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研究業績
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2004年

Subrina Jesmin, Hiroko Togashi, Ichiro Sakuma, Chishimba N. Mowa, Ken-ichi Ueno, Taku Yamaguchi, Mitsuhiro Yoshioka, Akira Kitabatake: Gonadal Hormones and Frontocortical Expression of Vascular Endothelial Growth Factor in Male Stroke-Prone, Spontaneously Hypertensive Rats, a Model for Attention-Deficit/Hyperactivity Disorder. Endocrinology 145:4330-4343, 2004

Hidetsugu Sakai, Kazushi Urasawa, Naotsugu Oyama, Akira Kitabatake: Distal shower embolization during directional coronary atherectomy and stenting for diffuse stenosis of right coronary artery-Current limitations of intravascular ultrasonography for evaluating fragile plaque- Circulation Journal 68:257-262, 2004

Urasawa K, Sakai H, Saito T, Oyama N, Kaneta S, Kitabatake A: Wire-induced Myocardial Ischemia: A Novel Approach to Create Myocardial Ischemia in Rats. Circulation Journal 68:371-375, 2004

Y. Iwado, H. Furuyama, K. Yoshinaga, M. Mabuchi, Y. Ito, K.Noriyasu, T. Kohya, A. Kitabatake, E. Tsukamoto, N. Tamaki: Transient left ventricular dysfunction in ischaemic myocardium after stress: comparative study with exercise and pharmacological stress gated myocardial single photon emission computed tomography. Nuclear Medicine Communications 24:551-557, 2004

Kazusaku Kamiya, Makoto Kaneda, Takashi Sugawara, Emi Mazaki, Nami Okamura, Mauricio Montal, Naomasa Makita, Masaki Tanaka, Katsuyuki Fukushima, Tateki Fujiwara, Yushi Inoue, Kazuhiro Yamakawa: A Nonsense Mutaion of the Sodium Channel Gene SCN2A in a Patient with Intractable Epilepsy and Mental Decline. The Journal of Neuroscience 24:2690-2698, 2004

Tomoo Furumoto, Satoshi Fujii, Keiko Nishihara, Satoshi Yamada, Kaoru Komuro, Kazutomo Goto, Hisao Onozuka, Taisei Mikami, Akira Kitabatake, Burton E. Sobel: Maladaptive arterial remodeling with systemic hypertension associated with increased concentration in blood of plasminogen activator inhibitor type-1 (PAI-1). Am J Cardiol 93:997-1001, 2004

Subrina Jesmin, Ichiro Sakuma, Yuichi Hattori, Akira Kitabatake: Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic meddle-aged female rats. Mol Cell Biochem 259:189-196, 2004

Naoyuki Matsuda, Subrina Jesmin, Yoshika Takahashi, Eiichiro Hatta, Masanobu Kobayashi, Kazuto Matsuyama, Nozomi Kawakami, Ichiro Sakuma, Satoshi Gando, Hiyoyuki Fukui, Yuichi Hattori, Roberto Levi: Histamine H1- and H2-Receptor Gene and Protein Levels Are Differentially Expressed in the Hearts of Rodents and Humans. J Pharmacol Exp Ther 309:786-795, 2004

Koh KK, Ahn JY, Han SH, Jin DK, Kim HS, Lee KC, Shin EK, Sakuma I: Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis. Atherosclerosis 174:379-383, 2004

Betsuyaku T, Yonezawa K, Kitabatake A: Percutaneous coronary intervention for central sleep apnoea with ischaemic cardiomyopathy. Acta Cardiol 59:63-65, 2004

Matsui Y, Nan J, Okamoto H, Kon S, Onozuka H, Akino M, Liu L, Morimoto J, Rittling SR, Denhardt D, Kitabatake A, Uede T: Role of Osteopontin IN Cardiac Fibrosis and Remodeling in Angiotensin II-Induced Cardiac Hypertrophy. Hypertension 43:1-7, 2004

A.K.M Tarikuz Zaman, Satoshi Fujii, Daisuke Goto, Tomoo Furumoto, Tetsuya Mishima, Yukihito Nakai, Jie Dong, Shogo Imagawa, Burton E. Sobel, Akira Kitabatake: Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity. Journal of Molecular and Cellular Cardiology 37:525-535, 2004

Kwang Kon Koh, Ichiro Sakuma: Should Progestins Be Blamed for the Failure of Hormone Replacement Therapy to Reduce Cardiovascular Events in Randomized Controlled Trials? Arterioscler Thromb Vasc Biol 24:1171-1179, 2004

Kwang Kon Koh, Mi-Seung Shin, Ichiro Sakuma, Jeong Yeal Ahn, Dong Kyu Jin, Hyung Sik Kim, Dae Sung Kim, Seung Hwan Han, Wook-Jin Chung, Eak Kyun Shin: Effects of Conventional or Lower Doses of Hormone Replacement Therapy in Postmenopausal Women. Arterioscler Thromb Vasc Biol 24:1516-1521, 2004

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka, Akira Kitabatake: Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access. Mol Pharmacol 66:330-336, 2004

Miyuki Tsutihashi, Hiroyuki Tsutsui, Hideo Tada, Miwako Shihara, Akira Takeshita, Suminori Kono: Volume-Outcome Relation for Hospitals Performing Angioplasty for Acute Myocardial Infarction -Results From the Nationwide Japanese Registry-. Circulation Journal 68:887-891, 2004

Okita K, Nishijima H, Murakami T, Nagai T, Morita N, Yonezawa K, Iizuka K, Kawaguchi H, Kitabatake A: Can Exercise Training With Weight Loss Lower Serum C-Reactive Protein Levels? Arterioscler Thromb Vasc Biol 24:1868-1873, 2004

Morita N, Iizuka K, Okita K, Oikawa T, Yonezawa K, Nagai T, Tokumitsu Y, Murakami T, Kitabatake A, Kawaguchi H: Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts. Am J Physiol Endocrinol Metab 287:E1064-E1069, 2004

Nagai T, Okita K, Yonezawa K, Yamada Y, Hanada A, Ohtsubo M, Morita N, Murakami T, Nishijima H, Kitabatake A: Comparisons of the skeletal muscle metabolic abnormalities in the arm and leg muscles of patients with chronic heart failure. Circ J 68:573-579, 2004

Oikawa K, Iizuka K, Murakami T, Nagai T, Okita K, Yonezawa K, Kitabatake A, Kawaguchi H: Pure pressure stress increased monocarboxylate transporter in human aortic smooth muscle cell membrane. Mol Cell Biochem 259:151-156, 2004

Keiichiro Yoshinaga, Chietsugu Katoh, Kazuyuki Noriyasu, Yasuyoshi Iwado, Hideto Furuyama, Yoshinori Ito, Yuji Kuge, Tetsuro Kohya, Akira kitabatake, Nagara Tamaki: Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: A study using oxygen 15-labeled water PET. The Journal of Muclear Cardiology 10:275-283, 2004

S Jesmin, C N Mowa, I Sakuma, N Matsuda, H Togashi, M Yoshioka, Y Hattori, A Kitabatake: Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood. Journal of Molecular Endocrinology 33:343-359, 2004

Masaki Ikeuchi, Hiroyuki Tsutsui, Tetsuya Shiomi, Hidenori Matsusaka, Shouji Matsushima, Jing Wen, Toru Kubota, Akira Takeshita: Inhibition of TGF-β signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovascular Research 64:526-535, 2004

Tsutoshi Hattori, Hiroaki Shimokawa, Midoriko Higashi, Junko Hiroki, Yasushi Mukai, Hiroyuki Tsutsui, Kozo Kaibuchi, Akira Takeshita: Long-Term Inhibition of Rho-Kinase Suppresses Left Ventricular Remodeling After Myocardial Infarction in Mice. Circulation 109:2234-2239, 2004

Koichi Okita, Hirotaka Nishijima, Takeshi Murakami, Tatsuya Nagai, Noriteru Morita, Kazuya Yonezawa, Kenji Iizuka, Hideaki Kawaguchi, Akira Kitabatake: Can Exercise Training With Weight Loss Lower Serum C-Reactive Protein Levels? Arterioscler Thromb Vasc Biol 24:1868-1873, 2004

Keiichiro Yoshinaga, Chietsugu Katoh, Rob S.B. Beanlands, Kazuyuki Noriyasu, Kaoru Komuro, Satoshi Yamada, Yuji Kuge, Koichi Morita, Akira Kitabatake, Nagara Tamaki: Reduced oxidative metabolic response in dysfunctional myocardium with preserved glucose metabolism but with impaired contractile reserve. J Nucl Med 45:1885-1891, 2004

Betsuyaku T, Yonezawa K, Sakurai M, Kitabatake A: Positional ventricular tachycardia. Pacing Clin Electrophysiol 27:1437-1439, 2004

Sakai H, Urasawa K, Oyama N, kitabatake A: Successful covering of a hepatic artery aneurysm with a coronary stent graft. Cardiovasc Intervent Radiol 27:274-277, 2004

T. Watanabe, T. Miyatake, H. Kumamoto, N. Mafune, S. Kubota, H. Okamoto, T. Murashita, T. Uede, K. Yasuda: Adenovirus-mediated CTLA4 immunoglobulin G gene therapy in cardiac xenotransplantation. Transplantation Proceedings 36:2478-2479, 2004

Matsui Y, Okamoto H, Jia N, Akino M, Uede T, Kitabatake A, Nishihira J: Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis. J Mol Cell Cardiol 37:557-566, 2004

Otani H, Jesmin S, Togashi H, Sakuma I, Nakai K, Satoh H, Yoshioka M, Kitabatake A: An S-nitrosylated hemoglobin derivative protects the rat hippocampus from ischemia-induced long-term potentiation impairment with a time window. J Pharmacol Sci 96:188-198, 2004

Subrina Jesmin, Ichiro Sakuma, Hiroko Togashi, Taku Yamaguchi, Ken-ichi Ueno, Mitsuhiro Yoshioka, Yuichi Hattori, Akira Kitabatake, Takashi Miyauchi: Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage. J Cardiovasc Pharmacol TM 44:S11-S15, 2004

Subrina Jesmin, Ichiro Sakuma, Yuichi Hattori, Akira Kitabatake, Takashi Miyauchi: The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model. J Cardiovasc Pharmacol TM 44:S49-S53, 2004

Subrina Jesmin, Ichiro Sakuma, Hiroko Togashi, Mitsuhiro Yoshioka, Yuichi Hattori, Akira Kitabatake, Takashi Miyauchi: Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP. J Cardiovasc Pharmacol TM 44:S59-S63, 2004

Subrina Jesmin, Ichiro Sakuma, Hiroko Togashi, Mitsuhiro Yoshioka, Yuichi Hattori, Akira Kitabatake, Takashi Miyauchi: Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker. J Cardiovasc Pharmacol TM 44:S156-S159, 2004

Subrina Jesmin, Ichiro Sakuma, Hiroko Togashi, Mitsuhiro Yoshioka, Yuichi Hattori, Akira Kitabatake, Takashi Miyauchi: Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker. J Cardiovasc Pharmacol TM 44:S160-S164, 2004

Miake J, Kurata Y, Iizuka K, Furuichi H, Manabe K, Sasaki N, Yamamoto Y, Hoshikawa Y, Taniguchi S, Yoshida A, Igawa O, Makita N, Shiota G, Nanba E, Ohgi S, Narahashi T, Hisatome I: State-dependent blocking actions of azimilide dihydrochloride (NE-10064) on human cardiac Na+ channels. Circ J 68:703-711, 2004

Oginosawa Y, Nagatomo T, Abe H, Makita N, Makielski JC, Nakashima Y: Intrinsic mechanism of the enhanced rate-dependent QT shortening in R1623Q mutant of the LQT3 syndrome. Cardiovasc Res 65:138-147, 2004

Jesmin S, Gando S, Matsuda N, Sakuma I, Kobayashi S, Sakuraya F, Hattori Y: Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors. Thromb Haemost 92:966-979, 2004

Mowa CN, Jesmin S, Sakuma I, Usip S, Togashi H, Yoshioka M, Hattori Y, Papka R: Characterization of Vascular Endothelial Growth Factor (VEGF) in the Uterine Cervix over Pregnancy: Effects of Denervation and Implications for Cervical Ripening. J Histochem Cytochem 52:1665-1674, 2004

Subrina Jesin, Hiroko Togashi, Chishimba N. Mowa, Ken-ichi Ueno, Taku Yamaguchi, Akiko Shibayama, Takashi Miyauchi, Ichiro Sakuma, Mitsuhiro Yoshioka: Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHRSP and SHR. Brain Research 1030:172-182, 2004

Noriko Oyama, Naotsugu Oyama, Kaoru Komuro, Toshikazu Nambu, Warren J Manning, Kazuo Miyasaka: Computed Tomography and Magnetic Resonance Imaging of the Pericardium: Anatomy and Pathology. Magnetic Resonance in Medical Sciences 3:145-152, 2004

Takehara N, Makita N, Kawabe J, Sato N, Kawamura Y, Kitabatake A, Kikuchi K (2004): A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill. J Int Med 255; 137-142, 2004

Kamiya K, Kaneda M, Sugawara T, Mazaki E, Okamura N, Montal M, Makita N, Tanaka M, Fukushima K, Fujiwara T, Inoue Y, Yamakawa K (2004): A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. J Neurosci 24; 2690-2698, 2004